Therefore, the lineage-specific differentiation of immature CD4+CD8+ (CD4 Antigen Positive CD8 Antigen Positive) T-cells into CD4+ or CD8+ mature T-cells is regulated by clonally-expressed, somatically-generated TCRs (T-Cell Receptors) of unpredictable fine specificity. These clonal receptors help to determine which precursor lymphocytes will successfully mature. But, adaptive immunity depends on the function of T- and B-cells, which express unique surface receptors that are created by somatic DNA rearrangement and random chain pairing. Signals from broadly expressed receptors that interact with co-evolved germline ligands control most differentiation decisions. The physiological function of a multicellular organism depends on the generation of the proper number and diversity of cell types.
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